A7229
Sigma
PUGNAc
| Synonym: | O-(2-Acetamido-2-deoxy- |
| CAS Number: | 132489-69-1 |
| Linear Formula: | C15H19N3O7 |
| Molecular Weight: | 353.33 |
| Beilstein Registry Number: | 4274031 |
Description
| Biochem/physiol Actions | PUGNAc is an in vitro and in vivo inhibitor of peptide O-GlcNAc-β-N-acetylglucosaminidase, the enzyme which removes O-linked N-acetylglucosamine (O-GlcNAc) from O-linked glycosylated proteins. |
Properties
| assay | ≥95% (HPLC) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Haltiwanger, R.S., et al., Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-β-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate. J. Biol. Chem. 273, 3611, (1998) |
| Dong, D.L. and Hart, G.W., Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J. Biol. Chem. 269, 19321, (1994) |
